Which vaccine is contraindicated in pregnancy due to its live-virus composition?

Which vaccine is contraindicated in pregnancy due to its live-virus composition?

• A. Influenza
• B. Rubella
• C. Tdap
• D. Hepatitis B

Answer: (B)

Live vaccines contain replication-competent viruses, which can pose a theoretical risk to the fetus if given during pregnancy. The rubella vaccine is a live-attenuated vaccine, and because of this potential risk, it is contraindicated in pregnant people. Administering it could expose the developing fetus to rubella virus, with potential for congenital rubella syndrome, especially in early pregnancy. After delivery, vaccination can be given to establish maternal immunity for future pregnancies. The other vaccines listed are inactivated or otherwise safe to administer during pregnancy, so they are not contraindicated.

Live vaccines contain replication-competent viruses, which can pose a theoretical risk to the fetus if given during pregnancy. The rubella vaccine is a live-attenuated vaccine, and because of this potential risk, it is contraindicated in pregnant people. Administering it could expose the developing fetus to rubella virus, with potential for congenital rubella syndrome, especially in early pregnancy. After delivery, vaccination can be given to establish maternal immunity for future pregnancies. The other vaccines listed are inactivated or otherwise safe to administer during pregnancy, so they are not contraindicated.